Those are two big things to overcome and basically have double-digit growth when you experience that type of generic competition.
If you had a generic Lipitor, it would be harder for Vytorin to compete. When you have a generic out there, you start worrying about therapeutic substitution.
The best defense against generic competition is innovation, because you don't have to worry so long as you come up with an innovative product that antiquates your older product, ... You can replace your own products before generic competition comes out.