There is an urgent need for a protective Ebola vaccine, and it is important to establish that a vaccine is safe and spurs the immune system to react in a way necessary to protect against infection.
If we could identify what that factor is -- and there's no guarantee we will, but if we can -- then one could direct your vaccine to elicit a response of that particular factor that is protecting them.
Historically, a live vaccine induces more potent, lasting and broader immune responses than a killed vaccine. The body is seeing the microbe in a way that is much more analogous to a real infection.
We have a vaccine we know can spur an immune response, albeit at very high doses. We're going in the right direction. The sobering news is we have a long way to go. So it's muted good news.
What this paper shows is you can make a vaccine against bird flu. It also points out a lot of weaknesses in the system. It's an important wake-up call.
The good news is that we have a vaccine that can induce an immune response. But the sobering news is . . . we have a long way to go.
The entire purpose of a vaccine is to mimic infection as best you can. Historically, a live vaccine induces more potent, lasting and broader immune responses than a killed vaccine. The body is seeing the microbe in a way that is much more analogous to a real infection.